• The Personalized Serum bottle on a plain white backdrop.
  • A woman holding the Personalized Serum bottle, serum on her cheek, beside the text: designed for your skin concerns, high concentration of clinically-proven actives, active ingredient percentages build over time.
  • A clear swipe of the serum, labelled: lightweight texture, supports visible skin longevity, fast-absorbing.
  • A hand pumping the Personalized Serum onto a fingertip.
  • The Personalized Serum bottle standing on the edge of a white plinth.

Personalized Serum

4.9 (116 reviews)

Targets your specific skin concerns with a high concentration of clinically-proven active ingredients. Lightweight texture enhances formula penetration for optimal results. Formulated for your skin type & concern.

Use
AM & PM
Size
30 ml
Lasts
2 months
Free shipping
Dr. Stanley HollmigDr. Amy YuanDr. Nicholas Conley
Reviewed by PROVEN's science board
Dr. Stanley Hollmig, MD, plus our physics and chemistry leads.

The Diagnostic

47 factors. Read together.

Because your skin isn't shaped by just one thing — and a formula built around one input misses the rest.

Concerns

Hyperpigmentation, fine lines, sensitivity, breakouts — every concern you flag becomes a factor in your formula. Each one gets weighted by severity, not treated in isolation.

Environment

UV index, humidity, hard water, air quality, altitude — read by your ZIP code and refined every shipment. Where you live shapes what your skin needs as much as what you do.

Lifestyle

Sleep, stress, hydration, screen time, sun exposure, alcohol, exercise — the daily inputs that quietly change how your skin behaves. Updated whenever you tell us what's changed.

Biology

Age, gender, skin type, skin tone, pregnancy — the foundation your formula is built on. Determines which actives are safe and at what concentrations.
Macro close-up of skin showing texture, fine lines and hyperpigmentation
Your Concerns6 mapped
  • Redness — severity 82 of 100
  • Loss of firmness — severity 74 of 100
  • Hyperpigmentation — severity 68 of 100
  • Sensitivity — severity 56 of 100
  • Fine lines — severity 42 of 100
  • Acne — severity 31 of 100

Your Formula

Clinical-grade actives. Calibrated.

Each formula draws from a library of 100+ ingredients — chosen, dosed, and sequenced for your skin.

Dark spots lifted, tone evened.

Pigment runs on four mechanisms. Single actives target one. Your serum stacks 10–16, dosed to your tone.

  • Vitamin C

    Vitamin C

    Brightens pigment and shields against oxidative damage.

    BrightensAntioxidant
  • Arbutin

    Arbutin

    Inhibits the enzyme that makes melanin, at the source.

    Targets melaninLightens
  • Bakuchiol

    Bakuchiol

    Drives turnover the way retinol does, without the sting.

    RenewsGentle

10–16 actives per formula.

Every PROVEN regimen draws from a 100+ ingredient library. The Skin Genome decides which actives, at what concentrations, in what sequence.

Your Ritual

How to use.

Morning and night — it takes under a minute.

  1. Step 1Cleanse first

    Serum goes on clean skin. Anything left on the surface blunts how much gets through.

  2. Step 2Apply once or twice a day

    Three or four drops, pressed into slightly damp skin rather than rubbed. If your formula includes a retinoid, use it at night only and wear SPF the next day.

  3. Step 3Seal it in

    Follow with your moisturizer. The serum delivers the actives; the cream keeps them — and your water — where they belong.

  4. Step 4Stay consistent

    Use it every day. Your skin recalibrates over 8–12 weeks — and your formula evolves right along with it.

Product credentials

  • Developed with
    Dermatologists
  • Made
    in USA
  • Cruelty
    Free
  • U.S.
    Patented
  • Clean
    Ingredients
  • Non-Toxic
    Ingredients

From the community

Real skin. Real routines.

Creators trying PROVEN — first takes, check-ins, full-year arcs.

Reviews

All questions

Can I use it more than once a day?

Yes. The Serum can be used twice a day.

When in my skincare routine should I apply it?

After cleansing (and toning if applicable), before your moisturizer. Apply 1-2 pumps, wait for absorption, then apply your moisturizer.

Can I layer my serum with other products?

Yes. Apply your Serum first, then follow with your Day Moisturizer or Night Cream.

Does the serum contain strong actives?

Ingredients vary based on your personalization. Some formulas may include brightening or smoothing ingredients, while others may focus on hydration or comfort. Your quiz results guide the selection and strength of each active.

How is my Serum personalized?

Your Serum is powered by PROVEN’s Skin Health Index™—our revolutionary skincare database built from billions of validated data points, including peer-reviewed research, clinical studies, and real-world insights. Our SkintellectAI™ technology then translates those insights into precise, personalized formulations that adapt to your unique skin profile, environment, and evolving needs.

How long until I see results?

First visible differences — tone, hydration, comfort — show up around week 2 for most customers. Deeper changes (texture, firmness, pigment, fine lines) build over 8–12 weeks as the actives accumulate. The 12-week mark is when most customers see measurable change across every concern their formula was built to address.

Will my formula actually change over time?

Yes. Adaptive Formula reviews your profile before every shipment — against the season, your skin's reported progress, and any change you've flagged in a follow-up quiz. Most adjustments are small (a concentration shift, a new ingredient swapped in), but every batch is reviewed. The point isn't that the formula changes constantly — it's that the formula tracks you instead of you tracking it.

What if it doesn't work?

30-day money-back guarantee. No questions, no return shipping cost. If something isn't right, message your skincare advisor — most issues are solved by a formula adjustment, not a refund. Either way, the risk is on us.

Can I pause or cancel my subscription?

Anytime. Skip a shipment, change your cadence, pause for travel, or cancel — all in your account, no email or call required. The system reformulates whenever you reorder, even if there's a long gap between shipments.

How is this different from Curology?

Curology builds one prescription serum that treats one concern (typically acne or aging). PROVEN builds a full 3-step routine that treats every concern on your skin at once — main and secondary — and updates the formula based on your skin's progress and the season. Curology treats one thing. PROVEN treats all of it.

What if my skin is sensitive?

Sensitivity is one of the 47 factors the diagnostic reads. If your skin is reactive, your formula is built around lower-strength actives, barrier-rebuilding ingredients, and a sequence that introduces stronger components gradually. Customers with sensitive skin make up 41% of our subscriber base.

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